Carpal tunnel syndrome is a condition in which the median nerve becomes entrapped at the wrist in the carpal tunnel.
- Paresthesia – numbness, needles and pins
- Lost of strenght
in the distribution area of the median nerve. The symptoms are often aggravated at night time.
Electrodiagnostic tests: nerve conduction study or electromyography.
Nine flexor tendons and the median nerve pass through the carpal tunnel that is surrounded on three sides by the carpal bones that form an arch.
It appears to be caused by a combination of genetic and environmental factors. In many cases the carpal tunnel is generally narrow, and prior carpal tunnel syndrome surgery is very common in individuals who later present with transthyretin amyloid-associated cardio-myopathy, suggesting that transthyretin amyloid deposition may cause carpal tunnel syndrome. 
Atrophy of the thenar muscles as a result of untreated carpal tunnel syndrome. When there is constant numbness, atrophy or weakness over a longer period of time, carpal tunnel release surgery is indicated to release the transverse carpal ligament.
Compression of the median nerve 
 Carpal tunnel syndrome. (n.d.). In Wikipedia. Retrieved on 23 February 2013 from http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome
 Darling David. (n.d.). Carpal Tunnel Syndrome. Retrieved on 23 February 2013 from http://www.daviddarling.info/encyclopedia/C/carpal_tunnel_syndrome.html